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Potential therapeutic targets for autism have been identified

diplomaiewn 於 2017年08月14日發表   人氣:288


Hu Ronggui research team, An oil vaporizer runs on oil vape pen battery which needs charging. Now imagine one that takes long hour to pre-heat! Isn't that irritating? So, it's always better to buy an oil vape pen battery from reputed online sites!Institute of Biochemistry and cell biology, Chinese Academy of Sciences, Shanghai Institute of Biological Sciences recently clarified the new mechanism of human autism, and found potential targets for autism treatment. Related research papers recently published online in the journal "cell research" magazine.

 

Autism spectrum disorder (ASD), referred to as autism, also known as autism, is a serious neurodevelopmental disorder. The research shows that since mid 1990s, in autism patients, chromosome 15q11-q13 amplification (CNV) of the proband accounted for more than 1%~3%, the ubiquitin ligase UBE3A gene leads to the overexpression of autism is one of the important factors in the.

 

Researchers through biochemical and electrophysiological studies showed that UBE3A reduced neuronal cells leads to excessive retinoic acid levels, and the destruction of synaptic plasticity, and may participate in the occurrence of autism. In the over expression of UBE3A in mice showed that autism model in the experiment, all trans retinoic acid oral dose was found to significantly alleviate a series of similar characteristics of autism behavior of autistic mice, this is for some subset of autism clinical intervention provides very promising molecular targets and early on the basis of.

 

Researchers have found that inhibitors of ALDH1A (also called Disulfiram, melphalan) can trigger autism specific behaviors in mice, and can also be alleviated by oral administration of retinoids. This shows that on the one hand to strengthen the "logical relation between retinoic acid synthesis inhibition and autism behavior, on the other hand also remind people in current practice approved that the safe use of drugs may increase the risk of fetal or children with autism.

 

Experts believe that the study reveals new pathogenesis of familial human autism spectrum disorder, clear support and further interpretation of the "human autism is a developmental defect in the nervous system, is also a kind of neural system disease" concept; from the new angle of the molecular mechanism of ASD, brings new ideas for the prevention and treatment of human ASD.

 

 


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